关键词: 致病基因预测, 相关性计算, 异质信息网络, HeteSim方法, 元路径

Abstract: A growing number of evidences indicate that long non-coding RNAs (lncRNAs) play important roles in many biological processes, and mutations or dysfunction in these long non-coding RNAs can cause serious diseases in human bodies, such as various cancers. Biological methods have been exploited to predict potential associations between diseases and long non-coding RNAs, which are of great significance for the exploration of pathogenesis, diagnosis, treatment, prognosis and prevention of complex diseases. Heterogeneous information network is constructed based on the known disease-gene associations. The association strength between lncRNAs and diseases can be measured by an association score in the heterogeneous network. A simple method called HeteSim is applied to calculate the association scores between lncRNAs and diseases. The method used in this paper is based on all paths existing between a given disease and a given lncRNA. The experiments show that our method can achieve superior performance than state-of-art methods.Our predictions for ovarian cancer and gastric cancer have been verified by biological experiments, indicating the effectiveness of this method. The case studies indicate that our method can give informative clues for further investigation. In conclusion, the only paths based on known disease-gene associations are exploited, and it is can be expected that other disease associated information can also be integrated into our method, and better performance can be available.

Key words: disease-gene prediction, correlation calculation, heterogeneous information networks, HeteSim, meta-path