Abstract: Described in this paper is a computing grid, the drug discovery grid （DDG）, which utilizes the distributed resources to implement the efficient computing-intensive/data-intensive drug-design applications in the Internet.Discussed in detail are the multilevel parallel P2P technologies, the self-adaptive dynamical load balancing schedule technologies, the grid resources’ fault tolerance technologies, and the system security technologies.The experimental results show that the DDG’s load balance is effective and robust and the drug-design application has good parallel acceleration in the large-scale Internet environment.