Abstract: The characteristics of a workflow system oriented toward the knowledge based application and interaction are firstly summarized according to the categories of the workflow system, and the framework of process unit is proposed as the elementary fragments for workflow modeling in conformance with the aggregation of knowledge and propagation of information The fundamental environment underlying the systemic modeling oriented toward the knowledge based application and interaction is structured based on the inter relations among the process units By means of an instance of software development, the implementation steps are explicated in diagrams For highlighting the supervision of the knowledge based application and interaction, the topic of control flow is brought into research A hierarchical control based on area specified interaction is presented and the rules observed during performance are defined for decomposing the control logic The concluding remarks about the development of the workflow system are brought forward, and some hotspots in research are discussed, too