Abstract: Interoperability is one of the key problems, which must be solved in distributed computing systems. The distributed integrated framework is a good solution for interoperability. First studied in this paper are the concept and implementation mechanism of the interoperability, and the mechanism with which object oriented technology supports interoperability. Then, after comparing the DCE RPC mechanism with the CORBA ORB mechanism, research on the distributed client/server integrated framework is carried out based on the agent using the object oriented method and technology, and a generic framework is presented based on multiple agent, to support client/server computing application development and to support the interoperability among agents.